ʻO Glutaraldehyde Technological Frontier: Heʻe i ka ʻenehana Anti-Calcification

Ma ke kahua o nā implants cardiovascular, ua hoʻohana lōʻihi ʻia ka glutaraldehyde e mālama i nā ʻiʻo holoholona (e like me ka bovine pericardium) no ka hana ʻana i nā kiwi bioprosthetic. Eia nō naʻe, hiki i ke koena o nā pūʻulu aldehyde manuahi mai nā kaʻina hana kuʻuna hiki ke alakaʻi i ka calcification post-implantation, e hōʻemi ana i ka lōʻihi o ka lōʻihi o nā huahana.

I ka hoʻoponopono ʻana i kēia pilikia, ua hoʻopuka kahi noiʻi hou i paʻi ʻia ma ʻApelila 2025 i kahi hopena lapaʻau anti-calcification hou (inoa huahana: Periborn), e loaʻa ana ka holomua kupaianaha.

1. Hoʻonui ʻenehana kumu:

Hoʻopuka kēia hāʻina i kekahi mau hoʻomaikaʻi koʻikoʻi i ke kaʻina hana kuʻuna glutaraldehyde cross-linking:

ʻO ka hoʻoheheʻe ʻana i nā mea hoʻoheheʻe organik:
Hana ʻia ʻo Glutaraldehyde cross-linking i loko o kahi mea hoʻoheheʻe organik i haku ʻia me 75% ethanol + 5% octanol. Kōkua kēia ala i ka hoʻoneʻe ʻana i nā phospholipid kiko i ka wā o ka cross-linking - ʻo ka phospholipids ka pae nucleation mua no ka calcification.

Luna Hoopiha Lewa:

Ma hope o ka hoʻopili ʻana, hoʻohana ʻia ka polyethylene glycol (PEG) ma ke ʻano he mea hoʻopiha piha, e hoʻopili ana i nā āpau ma waena o nā fiber collagen. Mālama kēia i nā wahi nucleation o nā kristal hydroxyapatite a pale i ka infiltration o ka calcium a me nā phospholipids mai ka plasma host.

Hoʻopaʻa hoʻopaʻa ʻana:

ʻO ka mea hope loa, ʻo ka lapaʻau ʻana me ka glycine e hoʻokaʻawale i ke koena, nā pūʻulu aldehyde manuahi reactive, a laila e hoʻopau i kekahi kumu nui e hoʻoulu ai i ka calcification a me ka cytotoxicity.

2. Nā hopena lapaʻau koʻikoʻi:

Ua hoʻohana ʻia kēia ʻenehana i kahi scaffold pericardial bovine i kapa ʻia ʻo "Periborn." Ua hōʻike ʻia kahi noiʻi maʻi maʻi e uhi ana i nā mea maʻi 352 ma luna o 9 mau makahiki i ke kūʻokoʻa mai ka hana hou ʻana ma muli o nā pilikia pili i ka huahana e like me 95.4%, e hōʻoiaʻiʻo ana i ka pono o kēia hoʻolālā anti-calcification hou a me kāna mau lōʻihi lōʻihi.

ʻO ke koʻikoʻi o kēia holomua:

ʻAʻole wale ia e kamaʻilio i kahi paʻakikī lōʻihi ma ke kahua o nā valve bioprosthetic, e hoʻonui ana i ke ola o ka huahana, akā e hoʻokomo pū i ka ikaika hou i ka noi o ka glutaraldehyde i nā mea biomedical kiʻekiʻe.