ʻO ka loiloi o ka ʻike ʻana i ka hana i ka 4,4′-methylene-bis-(2-chloroaniline) "MOCA" e kahi ala maʻalahi hou no ka nānā ʻana i ke ola.

Ua hoʻomohala maikaʻi ʻia kahi ʻano analytical novel, i hōʻike ʻia e ka kikoʻī kiʻekiʻe a me ka naʻau ikaika, no ka hoʻoholo ʻana i ka 4,4′-methylene-bis-(2-chloroaniline), i kapa ʻia ʻo "MOCA," i loko o ka mimi kanaka. He mea nui e hoʻomaopopo i ka MOCA he carcinogen i kākau maikaʻi ʻia, me nā hōʻike toxicological i hoʻokumu ʻia e hōʻoia ana i kona carcinogenicity i nā holoholona laboratory e like me nā ʻiole, nā ʻiole, a me nā ʻīlio.

Ma mua o ka hoʻohana ʻana i kēia ʻano hana hou i kūkulu ʻia i nā ʻoihana ʻoihana honua maoli, ua hana mua ka hui noiʻi i kahi haʻawina mua pōkole me ka hoʻohana ʻana i nā ʻiole. ʻO ka pahuhopu nui o kēia noiʻi preclinical ʻo ia ka ʻike a me ka wehewehe ʻana i kekahi mau mea nui e pili ana i ka urinary excretion o MOCA i ke ʻano holoholona-me nā ʻano like me ka excretion rate, metabolic pathways, a me ka puka makani no nā pae ʻike ʻia-e kau ana i kahi kumu ʻepekema paʻa no ka hoʻohana ʻana o ke ʻano i nā laʻana kanaka.

Ma hope o ka pau ʻana a me ka hōʻoia ʻana o ka noiʻi preclinical, ua hoʻohana mua ʻia kēia ʻano hana ʻike mimi e loiloi i ka nui o ka ʻike ʻana i ka hana i MOCA ma waena o nā limahana ma nā ʻoihana ʻoihana Farani. Ua uhi ʻia ka laulā o ka noiʻi i ʻelua ʻano hana nui e pili pū ana me MOCA: ʻo ke kaʻina hana ʻenehana o MOCA ponoʻī, a ʻo kekahi ʻo ka hoʻohana ʻana iā MOCA ma ke ʻano he lāʻau lapaʻau i ka hana ʻana i nā elastomers polyurethane, kahi hiʻohiʻona hoʻohana maʻamau i ka ʻoihana kemika a me nā ʻoihana.

Ma o ka hoʻāʻo nui ʻana o nā laʻana mimi i hōʻiliʻili ʻia mai nā limahana i kēia mau hiʻohiʻona, ua ʻike ka hui noiʻi ua hōʻike ʻia ka nui o ka hoʻololi ʻana o ka urinary excretion o MOCA. ʻO ke kikoʻī, ʻo ka nui o ka excretion mai nā pae hiki ʻole ke ʻike ʻia-i wehewehe ʻia ma lalo o 0.5 micrograms no ka lita-i ka nui o 1,600 micrograms no ka lita. Eia kekahi, i ka wā i loaʻa ai nā metabolites N-acetyl o MOCA i loko o nā laʻana mimi, ua mau a haʻahaʻa loa ko lākou mau ʻike ma mua o ka nui o ka pūhui makua (MOCA) i nā laʻana like, e hōʻike ana ʻo MOCA ponoʻī ke ʻano mua i hoʻokuʻu ʻia i loko o ka mimi a me kahi hōʻailona hilinaʻi o ka ʻike.

Ma ke ʻano holoʻokoʻa, ʻike ʻia nā hopena i loaʻa mai kēia loiloi hōʻike ʻoihana nui e hōʻike pololei a pololei i nā pae hoʻolaha MOCA holoʻokoʻa o nā limahana i noiʻi ʻia, ʻoiai ua pili pono nā pae excretion i ʻike ʻia me ke ʻano o kā lākou hana, ka lōʻihi o ka hoʻolaha ʻana, a me nā kūlana hana. Eia kekahi, ʻo kahi ʻike koʻikoʻi mai ka noiʻi ʻana ma hope o ka pau ʻana o nā hoʻoholo analytical a ua hoʻokō ʻia nā hana pale i hoʻopaʻa ʻia ma nā wahi hana-e like me ka hoʻomaikaʻi ʻana i nā ʻōnaehana ventila, hoʻomaikaʻi i ka hoʻohana ʻana i nā lako pale pilikino (PPE), a i ʻole ka hoʻohana ʻana i nā kaʻina hana. MOCA.